Thermo Fisher Scientific NRG1 Polyclonal Antibody
NRG1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry 등에 사용 가능. Human 반응성 확인 및 다양한 조직 연구에 적합. Protein A 및 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Amphibian, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 198–229 from the central region of human NRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2236237 |
Target Information
Neuregulin 1 (NRG1) is a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase, leading to increased phosphorylation of tyrosine residues. The NRG1 gene produces multiple isoforms through alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms differ in structure and tissue-specific expression. HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF isoforms include a kringle-like sequence plus Ig and EGF-like domains, while SMDF shares only the EGF-like domain.
All NRG1 isoforms interact with ERBB family receptors, inducing growth and differentiation in epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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