Thermo Fisher Scientific uPAR Polyclonal Antibody
Thermo Fisher Scientific의 uPAR Polyclonal Antibody는 인간 uPAR 단백질을 인식하는 Rabbit IgG 기반 항체로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 높은 특이성과 안정성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human uPAR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792240 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Chimpanzee (100%).
- Positive Control: HeLa, U87-MG.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule regulating cell-surface plasminogen activation and plays an important role in both normal and pathological processes. The human PLAUR cDNA encodes 335 amino acids, including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein (~50 kDa) in monocytes, anchored to the plasma membrane via glycosyl-phosphatidylinositol linkage.
PLAUR (also known as UPAR) interacts with the carbohydrate-binding domain of SELL on neutrophil membranes, similar to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing up to a 33-fold increase in advanced clinical stages compared to normal tissue. UPAR protein expression correlates positively with recurrence and mortality rates in endometrial cancer patients. Thus, UPAR may serve as a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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