Thermo Fisher Scientific GPC3 Monoclonal Antibody (2C12)
Thermo Fisher Scientific의 GPC3 단클론 항체(2C12)는 인간 GPC3 단백질을 인식하는 Mouse IgM 항체입니다. Western blot과 ELISA에 적합하며, 비결합형 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C12 |
| Immunogen | GPC3 (NP_004475.1, 121 a.a. ~220 a.a) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS
Target Information
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression or modulation of growth in mesodermal tissues and organs. It may also modulate IGF2 interactions with its receptor. Members of the glypican family are anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage and play roles in cell division, growth regulation, and tumor predisposition.
Deletion mutations in GPC3 cause Simpson-Golabi-Behmel syndrome (SGBS), characterized by pre- and postnatal overgrowth with visceral and skeletal anomalies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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