Thermo Fisher Scientific GJB2 Monoclonal Antibody (1C6)
GJB2 단백질을 인식하는 mouse monoclonal antibody(1C6)로, Western blot과 ELISA에 최적화됨. Human 시료에 반응하며, PBS buffer에 보존된 액상 형태. Affinity chromatography로 정제된 연구용 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | GJB2 (AAH17048, 1 a.a. – 226 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MDWGTLQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRKFIKGE IKSEFKDIEE IKTQKVRIEG SLWWTYTSSI FFRVIFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV
Target Information
Gap junctions are conduits that allow direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, thereby mediating intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial roles in these channels.
Defects in GJB3 are linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient red patches or hyperkeratosis.
Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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