Thermo Fisher Scientific Tau Monoclonal Antibody (3D4), APC

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC: MA5-45955
• PerCP: MA5-45956
• Custom conjugation available upon request

Product Specific Information

A 1:1,000 dilution of MA5-45954 was sufficient for detection of Tau 2N4R P301S Fibril in 20 µg of Mouse Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects multiple bands. Antibody detects monomer and fibril under native conditions (dot blot).

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, acting as a linker between both structures.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), a hallmark of neurofibrillary lesions in Alzheimer’s disease and related disorders. Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration.
Tau phosphorylation is regulated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Abnormal Tau aggregation is associated with Alzheimer’s disease, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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