Thermo Fisher Scientific Tau Monoclonal Antibody (1D5), PerCP
Tau 단백질을 검출하기 위한 PerCP 결합 단클론 항체로 인간, 마우스, 랫트 반응성. Western blot, ICC/IF, ELISA, Dot blot 등 다양한 실험에 사용 가능. 단백질 G로 정제된 액상 형태로 제공되며, 4°C에서 보관. Alzheimer 등 신경퇴행성 질환 연구에 적합.
- 카탈로그번호
- MA545953
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Tau Monoclonal Antibody (1D5), PerCP
Thermo Fisher Scientific Tau Monoclonal Antibody (1D5), PerCP
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
| Dot blot (DB) | Assay-dependent |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D5 |
| Immunogen | Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils |
| Conjugate | PerCP |
| Excitation/Emission Max | 482/675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932407 |
Additional Formats
Product Specific Information
A 1:1,000 dilution of MA5-45953 was sufficient for detection of Tau 2N4R P301S Fibril in 20 µg of Mouse Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects multiple bands. Antibody detects monomer under denaturing conditions but preferentially detects fibril under native conditions (dot blot).
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between them.
In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer’s disease (AD) brain. Hyper-phosphorylation impairs microtubule binding, resulting in destabilization and neuronal degeneration.
Tau is phosphorylated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.