Thermo Fisher Scientific Phospho-p56-LCK (LSK) (Tyr505) Polyclonal Antibody
p56-LCK 단백질의 Tyr505 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 분석에 적합하며, 다양한 종(인간, 마우스, 랫 등)에 반응. 항원 친화 크로마토그래피로 정제된 고품질 연구용 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the carboxyl-terminus of p56lck protein with a phosphorylation site at Tyr 505 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Serum starved Jurkat cells
- Cellular location: Cytoplasm, Cell membrane
Target Information
LCK is a member of the Src-family tyrosine kinases, essential for signaling through the T-cell receptor (TCR) complex. Upon TCR activation, LCK phosphorylates the ITAM motifs in the zeta subunits, creating binding sites for the SH2 domains of ZAP70, which is subsequently phosphorylated and activated by LCK. This leads to downstream signaling via adaptor LAT phosphorylation.
Most LCK localizes to the plasma membrane, but a portion is associated with the Golgi apparatus, contributing to Raf activation under weak TCR stimulation. LCK contains N-terminal myristylation and palmitylation sites, a PTK domain, and SH2/SH3 domains mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. LCK also regulates apoptosis induced by various stimuli, though not via death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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