Thermo Fisher Scientific Phospho-TEK (Tyr897) Polyclonal Antibody
Phospho-TEK (Tyr897) 폴리클로날 항체로, 인산화된 TEK(TIE2) 단백질을 특이적으로 검출합니다. Western blot 및 IHC(파라핀)에서 사용 가능하며, 인간 및 마우스 시료에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol 저장 용액 형태로 제공됩니다.
- 카탈로그번호
- PA5105613
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TEK (Accession Q02763), corresponding to amino acid residues around phosphorylated Tyr897. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817041 |
Product Specific Information
This antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr897.
Target Information
The TEK receptor tyrosine kinase (TIE2) is expressed almost exclusively in endothelial cells. TEK signaling is essential for endothelial cell–smooth muscle cell communication during venous morphogenesis. Defects in TEK are linked to inherited venous malformations. Angiopoietin-1 binds to TEK and mediates signaling critical for embryonic vascular development. TIE2 expression is upregulated by thyroid-stimulating hormone and cAMP-elevating agents. Hematopoietic stem cells expressing TIE2 are quiescent, anti-apoptotic, and adhere to osteoblasts in the bone marrow niche.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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