Thermo Fisher Scientific Phospho-Btk (Tyr344) Polyclonal Antibody
BTK 단백질의 Tyr344 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 생쥐, 랫트 반응성. 고순도 정제, 1 mg/mL 농도, PBS/glycerol 버퍼, -20°C 보관.
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Thermo Fisher Scientific Phospho-Btk (Tyr344) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BTK (Accession Q06187), corresponding to amino acid residues around phosphorylated Tyr344 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817048 |
Product Specific Information
This antibody detects endogenous levels of BTK only when phosphorylated at Tyr344.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily. Mutations in the BTK gene are associated with developmental blocks in human B-cell ontogeny and immunodeficiency disorders. BTK interacts with Toll-like receptor (TLR) family members such as TLR4, 6, 8, and 9, which play key roles in innate and adaptive immunity. It also interacts with proteins involved in TLR4 signal transduction including MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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