Thermo Fisher Scientific Phospho-SHP2 (Tyr62) Polyclonal Antibody
Phospho-SHP2 (Tyr62) 폴리클로날 항체로 인간, 마우스, 랫트에서 반응. SHP2의 Tyr62 인산화 상태를 특이적으로 검출. Western blot과 IHC(Paraffin)에 적합. 고순도 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTPN11 (Accession Q06124), corresponding to amino acid residues around phosphorylated Tyr62 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817046 |
Product Specific Information
Antibody detects endogenous levels of SHP2 only when phosphorylated at Tyr62.
Target Information
The protein encoded by this gene belongs to the protein tyrosine phosphatase (PTP) family, which regulates numerous cellular processes such as growth, differentiation, and mitotic cycle. It contains two tandem Src homology-2 domains that mediate phospho-tyrosine binding and substrate interactions. SHP2 is widely expressed and plays a key role in cell signaling related to mitogenic activation, metabolism, transcription, and migration. Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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