Thermo Fisher Scientific Phospho-CXCR4 (Ser324, Ser325) Polyclonal Antibody
Phospho-CXCR4 (Ser324/Ser325) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에서 WB, IHC(F), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/BSA/glycerol buffer에 보관. CXCR4 단백질의 다양한 변형 형태 검출에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-CXCR4 (Ser-324/Ser-325) synthetic peptide (coupled to carrier protein), corresponding to amino acids surrounding Ser-324 and Ser-325 in the C-terminal region of human CXCR4. Sequence conserved in mouse, rat, and chicken CXCR4, but low homology to other CXCR family members. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942905 |
Product Specific Information
This antibody detects bands at 35, 42, 50, and 100 kDa corresponding to various post-translationally modified forms of CXCR4 on SDS-PAGE immunoblots of human Jurkat and PC3 cells stimulated with calyculin A. These bands co-migrate with similar bands detected with anti-CXCR4 (a.a. 322-329) and anti-CXCR4 (a.a. 328-338) antibodies.
Target Information
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and also for HIV-2 binding to CD4 through envelope glycoprotein gp120, promoting Env-mediated fusion. CXCR4 acts as the receptor for the chemokine CXCL12/SDF-1, mediating intracellular calcium increase and MAPK1/MAPK3 activation. It is involved in hematopoiesis, cardiac and vascular development, neuronal survival, and inflammatory responses. Antibodies to CXCR4 can block HIV-1 and HIV-2 fusion and infection of human target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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