Thermo Fisher Scientific ICAM-3 Monoclonal Antibody (MEM-171)
인간 ICAM-3 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry 및 IP 실험에 적합합니다. CD50(IGSF) D2 도메인에 결합하며, 액상 형태로 제공되고 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-171 |
| Immunogen | Human granulocytes (CD50/ICAM-3, UniProt ID: P32942-1, amino acids 1–547) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072542 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120–130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells, and Langerhans cells. It is negative on platelets and erythrocytes.
Target Information
CD50 (Intracellular Adhesion Molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes and serves as a counter-receptor for the LFA-1 integrin. It mediates adhesion between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation. ICAM-3 plays a critical role in initiating immune responses and interacts with CD209 (DC-SIGN) on dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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