Thermo Fisher Scientific HTR2C Recombinant Rabbit Monoclonal Antibody (9H8)
HTR2C 단백질을 표적으로 하는 Recombinant Rabbit Monoclonal Antibody (Clone 9H8). Western blot 및 IHC(P) 적용 가능. 인간 시료에 반응하며, 높은 특이성과 재현성을 제공. HEK293 세포 발현, 액상 형태, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H8 |
| Immunogen | A synthesized peptide derived from human 5HT2C Receptor (HTR2C, UniProt ID: P28335-1, antigen range: 416–431) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898284 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that binds to multiple receptor subtypes, including the 5-HT2 family of G-protein-coupled receptors. These receptors activate phospholipase C and D signaling pathways.
The HTR2C gene encodes the 2C subtype of the serotonin receptor, which undergoes RNA editing that alters amino acids within the second intracellular loop. This editing modulates receptor isoforms’ interaction with G proteins and signaling activation, affecting serotonergic neurotransmission in the central nervous system.
Studies have reported abnormal 5-HT2C editing patterns in depressed suicide victims.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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