Thermo Fisher Scientific ITCH Recombinant Rabbit Monoclonal Antibody (9C3)
ITCH 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 최적화되어 있습니다. HEK293 세포에서 발현되었으며, 1.6 mg/mL 농도의 액상 형태입니다. 인간 ITCH 유래 펩타이드(aa 27–41)를 면역원으로 사용하였고, 연구용으로만 제공됩니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9C3 |
| Immunogen | A synthesized peptide derived from human ITCH (aa 27–41) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898281 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. These proteins are E3 ubiquitin-ligase molecules that regulate key trafficking decisions, including targeting of proteins to proteasomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in immune response regulation by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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