Thermo Fisher Scientific TIM3 Recombinant Rabbit Monoclonal Antibody (BLR033F)
인간 TIM3 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow Cytometry에 사용 가능. HEK293 세포에서 발현되었으며 정제된 액상 형태로 제공. 4°C에서 보관하며 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 – 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 – 1:500 |
| Flow Cytometry (Flow) | 0.5 µL per 1 x 10^6 cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR033F |
| Immunogen | Recombinant protein representing the extracellular domain of human TIM3 (HAVCR2) (residues 22–201) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid Type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
It consists of an IgV-like domain, a mucin-like extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and autoimmune disease induction, regulating Th1-mediated immune responses and promoting immune tolerance.
It has pathological relevance in experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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