Thermo Fisher Scientific IDO1 Recombinant Rabbit Monoclonal Antibody (BLR031F)
IDO1 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF에 적합합니다. HEK293 세포에서 발현되었으며 항원 친화 크로마토그래피로 정제되었습니다. 인간 시료에 반응하며, 액상 형태로 4°C에서 보관합니다.
- 카탈로그번호
- A700031x (2개 옵션)
- 판매단위
- pk
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Thermo Fisher Scientific IDO1 Recombinant Rabbit Monoclonal Antibody (BLR031F)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR031F |
| Immunogen | Recombinant protein representing human Indoleamine 2,3-dioxygenase 1 (IDO1, residues 1–403) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 50 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | BBS, pH 8.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note:
- For ICC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE cell sections.
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of important regulatory molecules such as tryptophan, serotonin, and melatonin. This process initiates the formation of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, including macrophages and dendritic cells. During inflammation, interferons (IFNs) trigger IDO1 induction, which serves as an antimicrobial mechanism by degrading tryptophan and inhibiting the growth of pathogens.
Additionally, IDO1 plays a critical role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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