Thermo Fisher Scientific AFP Monoclonal Antibody (OTI4G9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal development.
In adults, AFP expression is often associated with hepatoma or teratoma, although hereditary persistence may occur without pathology.
AFP is considered the fetal counterpart of serum albumin, with both genes located in tandem on chromosome 4.
It exists in monomeric, dimeric, and trimeric forms and can bind copper ions, nickel ions, fatty acids, and bilirubin.
AFP levels in amniotic fluid are used to detect neural tube defects such as spina bifida and anencephaly.
Elevated serum AFP levels are observed in hepatocellular carcinoma, teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.