Thermo Fisher Scientific AFP Monoclonal Antibody (OTI3F1), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal development.
AFP expression in adults is often associated with hepatoma or teratoma, though hereditary persistence can occur without pathology.
AFP is considered the fetal counterpart of serum albumin; both genes are tandemly located on chromosome 4.
The protein exists in monomeric, dimeric, and trimeric forms, and can bind copper, nickel, fatty acids, and bilirubin.
AFP levels in amniotic fluid are used to screen for spina bifida and anencephaly, while elevated serum AFP is linked to hepatocellular carcinoma (HCC), teratoblastoma, colorectal, pancreatic, and germ cell cancers.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.