Thermo Fisher Scientific AFP Monoclonal Antibody (OTI4D8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal life. In adults, AFP expression is often associated with hepatoma or teratoma, though hereditary persistence may occur without pathology. AFP is the fetal counterpart of serum albumin, with both genes located tandemly on chromosome 4. It exists in monomeric, dimeric, and trimeric forms and can bind copper ions, nickel ions, fatty acids, and bilirubin.

AFP levels in amniotic fluid are used to screen for spina bifida and anencephaly, while elevated serum AFP is observed in hepatocellular carcinoma (HCC), teratoblastoma, colorectal, pancreatic, and germ cell cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.