Thermo Fisher Scientific CD50/ICAM3 Recombinant Rabbit Monoclonal Antibody (ICAM3, 2873R)
CD50/ICAM3 단백질을 인식하는 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. IHC(P) 등 다양한 면역염색 실험에 적합하며, 고순도 Protein A/G 정제 방식으로 생산되었습니다. 액상 형태로 제공되며, 4°C 보관이 권장됩니다.
- 카탈로그번호
- 3385-RBM6-P1
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ICAM3, 2873R |
| Immunogen | Recombinant full-length human ICAM3 protein (CD50, ICAM3; UniProt ID: P32942-1; Antigen Range: 1–547) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
It functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation.
ICAM-3 plays a key role in initiating immune responses on T cells and antigen-presenting cells and interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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