Thermo Fisher Scientific CD50/ICAM3 Recombinant Rabbit Monoclonal Antibody (ICAM3, 2873R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
It functions as an adhesive molecule mediating contact between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation.
ICAM-3 plays a key role in initiating immune responses on T cells and antigen-presenting cells and interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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