Thermo Fisher Scientific CLCN1 Polyclonal Antibody
CLCN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 고순도 Affinity Chromatography로 정제되었습니다. 연구용으로 근육 및 신경세포의 염소이온 채널 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 779–988 of human CLCN1 (NP_0000743) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854960 |
Product Specific Information
Immunogen sequence:
ARPTKKKTTQ DSTDLVDNMS PEEIEAWEQE QLSQPVCFDS CCIDQSPFQL VEQTTLHKTH TLFSLLGLHL AYVTSMGKLR GVLALEELQK AIEGHTKSGV QLRPPLASFR NTTSTRKSTG APPSSAENWN LPEDRPGATG TGDVIAASPE TPVPSPSPEP PLSLAPGKVE GELEELELVE SPGLEEELAD ILQGPSLRST DEEDEDELIL
Target Information
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.
CLCN1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLCN1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting.
CLCN2 is highly expressed in the epithelia of several organs including lung, suggesting CLCN2 may be a possible therapeutic target for cystic fibrosis.
CLCN3 expression is abundant in neuronal tissue, while CLCN4 expression is evident in skeletal and cardiac muscle as well as brain.
Mutations in the gene encoding CLCN5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria.
CLCN6 and CLCN7 are broadly expressed in several tissues including testis, kidney, brain, and muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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