Thermo Fisher Scientific CLASP2 Polyclonal Antibody
CLASP2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western Blot과 ELISA에 적합하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol 버퍼에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 220–400 of human CLASP2 (NP_001193973.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854958 |
Product Specific Information
Immunogen sequence:
NCTSKSVPVR RRSFEFLDLL LQEWQTHSLE RHAAVLVETI KKGIHDADAE ARVEARKTYM GLRNHFPGEA ETLYNSLEPS YQKSLQTYLK SSGSVASLPQ SDRSSSSSQE SLNRPFSSKW STANPSTVAG RVSAGSSKAS SLPGSLQRSR SDIDVNAAAG AKAHHAAGQS VRSGRLGAGA L
Target Information
CLASP2 is a microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. It is required for the polarization of cytoplasmic microtubule arrays in migrating cells toward the leading edge. CLASP2 may act at the cell cortex to enhance the rescue frequency of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical stabilizing activity is regulated in part by phosphatidylinositol 3-kinase signaling. CLASP2 also stabilizes microtubules at the kinetochore, which is essential for bipolar chromosome alignment during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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