Thermo Fisher Scientific LPIN1 Polyclonal Antibody
Thermo Fisher Scientific의 LPIN1 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하는 토끼 IgG 항체입니다. Western blot에 적합하며, LPIN1 단백질의 내부 펩타이드(500-600)에 대해 특이적으로 결합합니다. 액상 형태로 제공되며 항원 친화 크로마토그래피로 정제되었습니다.
- 카탈로그번호
- PA116998
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic internal peptide corresponding to residues 500–600 of human LPIN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2135913 |
Product Specific Information
- Suggested positive control: 3T3-L1 cell lysates, antigen standard for LPIN1 (transient overexpression lysate).
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2, and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. It selectively activates a subset of PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA.
LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency may lead to insulin resistance and lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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