Thermo Fisher Scientific LPIN1 Polyclonal Antibody
LPIN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. 인간, 마우스, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제. 3T3-L1 lysate 양성 대조 권장.
- 카탈로그번호
- PA116997
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1.0–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic internal peptide corresponding to an internal region (within residues 300–400) of human LPIN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 30% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2135897 |
Product Specific Information
- Suggested positive control: 3T3-L1 cell lysates, antigen standard for LPIN1 (transient overexpression lysate).
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, all containing a nuclear signal sequence, a conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates PGC-1A target pathways such as fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing PPARA expression. LPIN1 also suppresses lipogenesis and circulating lipid levels.
Excess LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency can lead to lipodystrophy and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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