Thermo Fisher Scientific Cytokeratin 10 (KRT10) (Suprabasal Epithelial Marker) Recombinant Rabbit Monoclonal Antibody (KRT10/1990R)
Recombinant rabbit monoclonal antibody recognizing Cytokeratin 10 (KRT10), a suprabasal epithelial marker. Validated for IHC applications in human and mouse tissues. Supplied unconjugated in liquid form, 1 mg/mL concentration, purified via Protein A/G....
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | KRT10/1990R |
| Immunogen | Recombinant human full-length KRT10 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Cytokeratins (CK) are intermediate filaments of epithelial cells, found in both keratinizing tissues (e.g., skin) and non-keratinizing cells (e.g., mesothelial cells). Although not typical markers for endothelial cells, cytokeratins have been detected in some microvascular endothelial cells.
At least 20 cytokeratin types (40–70 kDa, pI 5–8.5) can be identified via two-dimensional gel electrophoresis.
Biochemically, CKs are divided into two classes:
- Type I: Acidic polypeptides
- Type II: Basic polypeptides
Each epithelial cell expresses at least one member from each class.
Monoclonal antibodies to cytokeratin proteins are valuable markers for tumor identification and classification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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