Thermo Fisher Scientific CD244 (2B4) Monoclonal Antibody (M085)
인간 CD244 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, ELISA, IP에 적합합니다. Protein G로 정제된 액상 형태이며, 0.5 mg/mL 농도로 제공됩니다. CD244 신호전달 연구 및 NK 세포 활성 분석에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M085 |
| Immunogen | Clone (M085) was generated from a recombinant protein that included the extracellular region of human CD244 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942641 |
Product Specific Information
Clone M085 mouse monoclonal antibody detects a 110 kDa protein on SDS-PAGE native immunoblots of human THP1 monocytes.
The antibody detects only the native CD244 protein and the aldehyde-fixed CD244 protein.
It is suitable for native western blot, immunoprecipitation, immunocytochemistry, and ELISA capture applications.
Target Information
CD244 (Natural killer (NK) cell receptor 2B4/SLAMF4) is an Ig superfamily signaling lymphocyte activation molecule (SLAM) receptor.
It contains two extracellular Ig-like domains and a cytoplasmic domain with four immunoreceptor tyrosine-based switch motifs.
CD244 binds CD48, a transmembrane receptor expressed on hematopoietic cells, and its activity is regulated by adapter proteins SH2D1A/SAP and SH2D1B/EAT-2.
Downstream signaling involves VAV1, INPP5D/SHIP1, and CBL, leading to NK cell cytotoxicity, IFN-γ production, and granule exocytosis.
CD244 also regulates CD8+ T-cell proliferation and modulates inflammatory responses in dendritic cells.
In cancers, CD244 expression increases in intratumoral DCs and myeloid suppressor cells, and anti-CD244 therapies may enhance T-cell infiltration and inhibit tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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