Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (NeuN/7071R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events. Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17 — p53 and BRCA1. Tumor suppressor p53 maintains cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is linked to malignant cell growth and Li-Fraumeni syndrome. BRCA1 is directly involved in DNA repair and is recognized as a genetic determinant of early-onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland, and fallopian tubes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.