Thermo Fisher Scientific Phospho-Presenilin 1 (Ser353) Polyclonal Antibody
Phospho-Presenilin 1 (Ser353) 폴리클로날 항체로, 인간·마우스·랫트 시료에서 인산화된 Presenilin 1 검출에 적합. WB, IHC, ICC/IF에 사용 가능하며 고순도 정제 및 안정한 PBS/glycerol 용액 형태로 제공. 알츠하이머병 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PSEN1 (Accession P49768), corresponding to amino acid residues around phosphorylated Ser353 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903211 |
Product Specific Information
This antibody detects endogenous levels of Presenilin 1 only when phosphorylated at Ser353.
Target Information
Presenilin 1 (PSEN1) is a key component of the γ-secretase complex, which plays a crucial role in intramembrane proteolysis of several proteins, including the amyloid precursor protein (APP). Mutations in PSEN1 are associated with early-onset Alzheimer’s disease. The γ-secretase-mediated cleavage of APP can produce either non-toxic p3 peptides or neurotoxic Aβ peptides, the accumulation of which is linked to Alzheimer’s disease pathogenesis. Multiple isoforms of presenilin 1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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