Thermo Fisher Scientific Glucagon Recombinant Superclonal Antibody (3HCLC)

Applications

• Western Blot (WB): 2–3 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse, rat, rabbit, and porcine based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple recombinant monoclonal antibodies, offering both the sensitivity of polyclonal antibodies and the specificity and consistency of monoclonal antibodies.

Each lot is produced with a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability typical of polyclonal antibody production.

Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

Glucagon is a 29-residue polypeptide hormone (MW 3482) produced in the pancreas. A related hormone, enteroglucagon (oxyntomodulin), produced in the intestinal mucosa, extends the glucagon sequence by 8 residues at the C-terminus.

Biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis — effects antagonistic to insulin, leading to increased blood glucose levels.

Immunocytochemical studies show glucagon localized in alpha (A) cells, comprising 15–20% of pancreatic islet cells. These cells are typically found at the periphery of islets. Glucagon-related pathologies are mainly associated with glucagon-secreting tumors (glucagonomas).

Glucagon-specific antibodies are valuable as cell and tumor markers in immunohistochemical studies and as analytical tools for hormone quantification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.