Thermo Fisher Scientific KCNIP3 Polyclonal Antibody, MaxPab

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW 
ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF 
KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED 
FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR 
HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ KDENIMSSMQ LFENVI

Target Information

Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain, these channels prevent reverse-propagation of action potentials.

KChIPs (Kv channel interacting proteins) are calcium-binding proteins associated with Kv4 channels that modulate their function. There are three known KChIPs:

• KChIP1: expressed in the brain
• KChIP2: expressed in brain, heart, and lung (three isoforms: a, b, c)
• KChIP3 (calsenilin, DREAM): expressed in brain and testis

KChIP3 not only modulates Kv4 currents but also binds to the regulatory DRE and represses transcription from the early-response gene c-fos. It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator. KChIP3 is also associated with presenilins and implicated in β-amyloid formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.