Thermo Fisher Scientific CD209 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSDSKEPRLQ QLGLLEEEQL RGLGFRQTRG YKSLAGCLGH GPLVLQLLSF TLLAGLLVQV SKVPSSISQE QSRQDAIYQN LTQLKAAVGE LSEKSKLQEI YQELTQLKAA VGELPEKSKL QEIYQELTRL KAAVGELPEK SKLQEIYQEL TWLKAAVGEL PEKSKMQEIY QELTRLKAAV GELPEKSKQQ EIYQELTRLK AAVGELPEKS KQQEIYQELT RLKAAVGELP EKSKQQEIYQ ELTQLKAAVE RLCHPCPWEW TFFQGNCYFM SNSQRNWHDS ITACKEVGAQ LVVIKSAEEQ NFLQLQSSRS NRFTWMGLSD LNQEGTWQWV DGSPLLPSFK QYWNRGEPNN VGEEDCAEFS GNGWNDDKCN LAKFWICKKS AASCSRDEEQ FLSPAPATPN PPPA

Target Information

This gene encodes a transmembrane receptor commonly referred to as DC-SIGN, expressed on dendritic cells and macrophages. It plays a key role in innate immunity by recognizing diverse pathogens including parasites and viruses.
The protein has three domains:

1. N-terminal transmembrane domain
2. Tandem-repeat neck domain
3. C-type lectin carbohydrate recognition domain

The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor. The neck domain mediates homo-oligomerization, enhancing multivalent ligand binding. Variations in the neck domain repeats affect ligand-binding affinity.
DC-SIGN is closely related to L-SIGN (GeneID 10332), with distinct ligand-binding properties and tissue distribution. Alternative splicing generates multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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