Thermo Fisher Scientific ORC1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ORC1L amino acids 170–220. Suitable for Western blot at 1–3 µg/mL. Supplied as liquid form (0.5 mg/mL), unconjugated. Store at 4°C short term or -20°C long term. For research use only.
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- PA523390
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 170–220 of human ORC1L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540913 |
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, controlled by ubiquitin-mediated proteolysis after initiation of DNA replication.
This protein is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), involved in transcription silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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