Thermo Fisher Scientific PYK2 Monoclonal Antibody (M229)
PYK2 단백질을 인식하는 마우스 단클론 항체(M229)로, Western blot 및 Immunocytochemistry에 적합. 인간, 마우스, 랫트 반응성. 단백질 A 정제, 액상 형태, -20°C 보관. 세포 신호전달 및 암 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M229 |
| Immunogen | Clone M229 was generated from a recombinant human PYK2 protein that included amino acid residues in the C-terminal region. This sequence is conserved in rat and mouse PYK2, and has low homology to other related kinases. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942710 |
Product Specific Information
The antibody detects a 116 kDa band corresponding to PYK2 on SDS-PAGE immunoblots of mouse brain tissue.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, migration, adhesion, spreading, and bone remodeling. It plays a role in the regulation of the humoral immune response and is required for normal levels and migration of splenic B-cells. PTK2B functions in signaling downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress. Aberrant expression may contribute to cancer cell proliferation, migration, and invasion. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung, and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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