Thermo Fisher Scientific PrP Monoclonal Antibody (3F4)
인간 프리온 단백질(PrP)을 검출하는 마우스 단클론 항체 3F4 클론. Western blot 및 동결면역조직화학에 적합. 인간 및 일부 동물 종에 반응. 고순도 Protein A 정제, 안정적 PBS/BSA/glycerol 저장 buffer 포함.
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Thermo Fisher Scientific PrP Monoclonal Antibody (3F4)
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
- Immunohistochemistry (Frozen) [IHC (F)]: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F4 |
| Immunogen | Clone (3F4) was generated from a synthetic peptide derived from amino acids in the central region of human prion protein. This sequence is conserved in feline and hamster, but less conserved in rat and mouse Prion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942709 |
Product Specific Information
The antibody detects endogenous prion protein in human PC3 and A431 cell lines. It strongly detects human recombinant Prion protein and weakly detects bovine recombinant Prion protein.
Target Information
Human prion protein (PrP), also known as PRNP, is a GPI-anchored cell surface glycoprotein associated with lipid rafts and functioning as a signaling molecule.
PrP plays a role in apoptosis, epithelial cell proliferation, and junction protein distribution in human enterocytes.
Conversion of the normal cellular prion protein (PrPc) into the abnormal conformer (PrPSc) is a key step in prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD).
PrPc is rich in alpha-helices, while PrPSc has a higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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