Thermo Fisher Scientific PDPK1 Monoclonal Antibody (M146)
PDPK1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, 인간·생쥐·랫드 시료에 반응. Western blot 및 ICC/IF에 사용 가능. Protein A로 정제된 액상 형태이며, -20°C에서 보관. 인슐린 신호전달 및 대사 연구에 적합.
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Thermo Fisher Scientific PDPK1 Monoclonal Antibody (M146)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M146 |
| Immunogen | Clone M146 was generated from a recombinant protein containing amino acid residues in the C-terminal region of human PDK1. This sequence is highly conserved in rat and mouse PDK1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942708 |
Product Specific Information
The antibody detects a 65 kDa protein corresponding to the apparent molecular mass of PDK1 on SDS-PAGE immunoblots of human A431 cells and mouse brain.
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop.
It also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate.
Active Akt subsequently inactivates Glycogen Synthase Kinase 3 (GSK3), leading to activation of glycogen synthase and stimulation of glycogen synthesis.
Because of PDPK1’s role in insulin-induced glycogen synthesis and PKC activation, it is an important target for metabolic drug research.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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