Thermo Fisher Scientific FGFR1 Monoclonal Antibody (3D4F7)
FGFR1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Mouse Monoclonal Antibody. Western blot 및 ELISA에 적합하며 인간 시료에서 반응. 4°C 단기, -20°C 장기 보관 가능. 비결합형 액상 형태로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D4F7 |
| Immunogen | Purified recombinant extracellular fragment of human FGFR1 (aa22–376) fused with hIgGFc tag expressed in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet Ice |
| RRID | AB_10987136 |
Product Specific Information
MA5-15530 targets FGFR1 in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is purified recombinant extracellular fragment of human FGFR1 (aa33–423) fused with hIgGFc tag expressed in HEK293 cells.
MA5-15530 detects FGFR1 with a predicted molecular weight of approximately 92 kDa.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
This receptor family plays critical roles in mesoderm induction, patterning, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, generating multiple splice variants expressed differently during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are associated with various diseases, including Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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