Thermo Fisher Scientific FGFR1 Monoclonal Antibody (3D4F7)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15530 targets FGFR1 in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is purified recombinant extracellular fragment of human FGFR1 (aa33–423) fused with hIgGFc tag expressed in HEK293 cells.
MA5-15530 detects FGFR1 with a predicted molecular weight of approximately 92 kDa.

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
This receptor family plays critical roles in mesoderm induction, patterning, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, generating multiple splice variants expressed differently during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are associated with various diseases, including Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.