Thermo Fisher Scientific Angiotensinogen Monoclonal Antibody (1B1)
인간 AGT 단백질을 인식하는 마우스 단클론 항체로, WB, ICC/IF, ELISA에 적합합니다. 정제된 재조합 인간 AGT 단편을 면역원으로 사용하였으며, 약 53kDa 단백질을 검출합니다. 연구용으로 혈압 조절 관련 단백질 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B1 |
| Immunogen | Purified recombinant fragment of human AGT expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10982606 |
Product Specific Information
MA5-15531 targets AGT in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human AGT expressed in E. coli.
MA5-15531 detects AGT with a predicted molecular weight of approximately 53 kDa.
Target Information
The AGT gene encodes pre-angiotensinogen (angiotensinogen precursor), mainly expressed in the liver. It is cleaved by renin in response to low blood pressure to produce angiotensin I, which is further processed by angiotensin-converting enzyme (ACE) to generate angiotensin II, a physiologically active peptide.
This protein plays a key role in blood pressure regulation and is implicated in essential hypertension and preeclampsia. Mutations in AGT are associated with essential hypertension, renal tubular dysgenesis, non-familial atrial fibrillation, and inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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