Thermo Fisher Scientific CD70 Recombinant Rat Monoclonal Antibody (TAN1-6)
CD70에 특이적인 랫트 단클론 항체로, 마우스 CD70을 인식하며 T-B 세포 간 상호작용 연구에 적합. Western blot, ICC/IF, Flow cytometry 등 다양한 응용 가능. 재조합 방식으로 HEK293 세포에서 발현된 고순도 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TAN1-6 |
| Immunogen | This antibody was raised by immunising LOU rats with soluble recombinant CD70:Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074597 |
Product Specific Information
This antibody is specific for murine CD70, a 30–33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.
Target Information
The protein encoded by this gene belongs to the tumor necrosis factor (TNF) ligand family. It acts as a ligand for TNFRSF27/CD27 and is expressed on activated, but not resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances cytolytic T cell generation, and contributes to T cell activation. Additionally, it regulates B-cell activation, NK cell cytotoxic function, and immunoglobulin synthesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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