Thermo Fisher Scientific 4-1BB Ligand Chimeric Recombinant Rabbit Monoclonal Antibody (AT113-2)
4-1BB Ligand(CD137L)을 특이적으로 인식하는 재조합 토끼 단일클론 항체. 다양한 응용(WB, ICC/IF, Flow Cytometry, Inhibition Assay)에 사용 가능. HEK293 세포 발현, Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AT113-2 |
| Immunogen | Raised by immunising LOU rats with soluble recombinant 4-1BBL:Fc fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074594 |
Product Specific Information
Specificity: This antibody is specific for 4-1BB ligand (also known as CD137 ligand), a member of the TNF superfamily and a type II membrane protein.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is expressed on various cells including inflamed endothelial cells, enhancing extravasation of CD137L-expressing monocytes.
Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma) but not on Hodgkin or T-cell lymphomas. It is also expressed in carcinoma cell lines and may be involved in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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