Thermo Fisher Scientific TIM-3 Chimeric Recombinant Rabbit Monoclonal Antibody (2C12)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is specific for murine TIM-3, a Th1-specific cell surface protein. TIM-3 is a type I transmembrane protein containing an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion.
This antibody binds strongly to the BALB/c allele of TIM-3, while reactivity to the C57Bl/6 allele is significantly weaker.

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.

TIM3 is involved in macrophage activation and the induction of autoimmune diseases. It downregulates aggressive Th1-mediated immune responses and facilitates immune tolerance development.
Pathological significance has been linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.