Thermo Fisher Scientific TIM-3 Chimeric Recombinant Rabbit Monoclonal Antibody (2C12)
마우스 TIM-3 단백질에 특이적인 재조합 토끼 단클론 항체입니다. IHC, ICC, Flow Cytometry, ELISA 등 다양한 면역분석에 사용 가능합니다. 높은 특이성과 재현성을 제공하며, 단기 4°C, 장기 -20°C에서 보관합니다.
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- MA548155
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (IHC) | Assay-dependent | — |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | — |
| Flow Cytometry (Flow) | 1:100 | — |
| ELISA | 0.0169 ng/mL | — |
| Functional Assay | Assay-dependent | — |
| Inhibition Assays (IA) | Assay-dependent | — |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2C12 |
| Immunogen | This antibody was raised by immunising rats with TIM-3:Ig fusion protein emulsified in complete Freund’s adjuvant. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074598 |
Product Specific Information
This antibody is specific for murine TIM-3, a Th1-specific cell surface protein. TIM-3 is a type I transmembrane protein containing an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion.
This antibody binds strongly to the BALB/c allele of TIM-3, while reactivity to the C57Bl/6 allele is significantly weaker.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and the induction of autoimmune diseases. It downregulates aggressive Th1-mediated immune responses and facilitates immune tolerance development.
Pathological significance has been linked to experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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