Thermo Fisher Scientific TIMD4 Chimeric Recombinant Rabbit Monoclonal Antibody (5G3)

Applications 및 권장 희석 배수

Product Specifications

Product Specific Information

Specificity:
This antibody is specific for murine TIM-4, which unlike other TIM family members, is not expressed on T lymphocytes but rather found on antigen presenting cells such as lymphoid and myeloid dendritic cells and macrophages.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)-1 and -2 cell-mediated immunity.
TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production.
Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and, with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.