Thermo Fisher Scientific MMP19 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MMP19 amino acids 12–60. Validated for IHC (Paraffin) with dilution 1:50–1:200. Affinity-purified with >95% purity. Provided as unconjugated liquid form (1 mg/mL) for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 12–60 of Human MMP19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718904 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient with rheumatoid arthritis (RA). Its expression on activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells suggests a role in RA-associated joint tissue destruction.
MMP-19 is found in smooth muscle cells of the tunica media of large blood vessels in RA patients but not in endothelial cells. Acutely inflamed synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation indicates a role in angiogenesis.
MMP-19 is expressed as a single 2.7 kb transcript in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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