Thermo Fisher Scientific STIM2 Polyclonal Antibody
STIM2 단백질을 인식하는 Thermo Fisher Scientific의 sheep 유래 polyclonal antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 인간 시료 반응성, 고순도 affinity chromatography 정제, 장기 안정성 우수.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Stim II affinity purified antibody prepared from whole sheep serum produced by repeated immunizations with a synthetic peptide near the C-terminus of human Stim II. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
A BLAST analysis suggests cross-reactivity with mouse and human based on 100% sequence homology. Cross-reactivity with Stim II from other sources has not been determined.
Target Information
In T lymphocytes, Ca++ entry following antigen-receptor binding occurs through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels consist of ORAI1 and stromal interaction molecule 1 (STIM1), which acts as a Ca++ sensor and activates CRAC channels by migrating from ER-like Ca++ stores to the plasma membrane.
STIM2 acts to inhibit STIM1-mediated store-operated Ca++ entry and can form complexes with STIM1, suggesting a coordinated role in regulating Ca++ influx. At least three isoforms of STIM2 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 600-601-J51_STIM2_Q9P246-1_Sheep.svg, 600-601-J51_STIM2_Q9P246-1_Sheep_PDP.jpeg)
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