Thermo Fisher Scientific PLAU Monoclonal Antibody (OTI1D4), TrueMAB

Applications

• Western Blot (WB): 1:200

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The PLAU gene encodes a serine protease involved in extracellular matrix degradation, tumor cell migration, and proliferation.
A polymorphism in this gene is associated with late-onset Alzheimer’s disease and reduced fibrin-binding affinity.
This protein converts plasminogen to plasmin by cleaving an Arg-Val bond. Plasmin subsequently cleaves PLAU at a Lys-Ile bond, forming a two-chain derivative (HMW-uPA) connected by a disulfide bond.
HMW-uPA can be further processed into LMW-uPA, which remains proteolytically active but does not bind the uPA receptor.
Alternative splicing results in multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.