Thermo Fisher Scientific CD33 Monoclonal Antibody (WM-53 (WM53)), PE, eBioscience
인간 CD33 항원을 인식하는 WM-53 단클론 항체로, PE 형광 표지되어 유세포분석(Flow Cytometry)에 최적화됨. 혈액세포 계통 분석용으로 사용되며, 4°C 암소 보관. 다양한 형광체 버전 제공.
- 카탈로그번호
- 12-0338-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD33 Monoclonal Antibody (WM-53 (WM53)), PE, eBioscience
Applications
- Flow Cytometry (Flow): 5 µL (0.25 µg)/test
- View 20 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WM-53 (WM53) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10855035 |
Additional Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 496
- Brilliant UV 661
- Brilliant Violet 605
- Brilliant Violet 711
- FITC
- NovaFluor Blue 690
- NovaFluor Red 710
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- NovaFluor Yellow 755
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
Description:
The WM-53 monoclonal antibody reacts with human CD33, also known as GP67 and P67, a 67 kDa type I transmembrane glycoprotein that is part of the Siglec (sialic acid-binding Ig superfamily lectin) family. It is specific to the hematopoietic compartment and is expressed on monocytes, activated T cells, granulocytes, myeloid progenitors, and mast cells.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human lysed whole blood.
Recommended usage: 5 µL (0.25 µg) per test (final volume 100 µL).
Cell number: 10⁵–10⁸ cells/test (empirically determined).
Excitation / Emission:
488–561 nm / 578 nm
Laser Compatibility: Blue, Green, Yellow-Green Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD33 is a transmembrane protein of the Siglec family containing ITIM motifs that recruit SHP-1 and SHP-2 phosphatases for inhibitory signaling. It binds sialic acid residues on cell surfaces and serves as a therapeutic target for acute myeloid leukemia (AML). CD33 is expressed on myelomonocytic lineage cells, granulocyte and macrophage precursors, and peripheral monocytes, but not on pluripotent stem cells. It is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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