Thermo Fisher Scientific Phospho-Acetyl-CoA Carboxylase (Thr1196) Polyclonal Antibody
Phospho-Acetyl-CoA Carboxylase (Thr1196) 폴리클로날 항체로, 인산화된 ACC1 검출에 특이적입니다. Western blot, IHC, ICC/IF에 사용 가능하며, Rabbit IgG 기반 액상형 제품입니다. -20°C 보관, 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ACACA (Accession Q13085), corresponding to amino acid residues around phosphorylated Thr1196. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817057 |
Product Specific Information
This antibody detects endogenous levels of ACC1 only when phosphorylated at Thr1196.
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system and a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis.
There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is regulated at multiple levels — transcriptional, translational, and post-translational — including phosphorylation/dephosphorylation of serine residues and allosteric modulation by citrate or palmitoyl-CoA.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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