Thermo Fisher Scientific CD2 Monoclonal Antibody (OTI5A1), TrueMAB
인간 CD2 단백질을 인식하는 마우스 단클론 항체로 다양한 면역실험(WB, IHC, Flow)에 사용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. PBS/BSA/glycerol 버퍼에 저장되며 -20°C에서 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A1 |
| Immunogen | Full length human recombinant protein of human CD2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) of the human T-lymphocyte lineage expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, present on more than 95% of thymocytes, and found on some natural killer cells but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2 is the erythrocyte receptor or closely associated with it.
The CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells. Though the affinity is relatively low in solution, it is compensated within the two-dimensional cell-cell interface for tight adhesion.
T cell activation increases CD2 expression and lateral mobility, facilitating contact with CD58 and strengthening intercellular adhesion.
CD2 deficiency reduces intestinal inflammation and aids infection control. Diseases associated with CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymus absence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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