Thermo Fisher Scientific HIF3A Monoclonal Antibody (OTI2F7), TrueMAB
인간 HIF3A 단백질을 인식하는 단클론 항체로 Western blot에 적합합니다. OTI2F7 클론 기반 IgG1 형식이며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, PBS/1% BSA/50% 글리세롤 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 355–669 of human HIF3A produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha), and HIF-3 alpha, induce glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis.
These factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to create the HIF-1 complex, which binds the hypoxia responsive element (HRE) of target genes to activate transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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