Thermo Fisher Scientific Phospho-TLR5 (Tyr798) Polyclonal Antibody
TLR5 단백질의 Tyr798 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며, Human과 Mouse 시료에 반응. 고순도 액상 형태로 -20°C 보관, 연구용으로 적합.
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- PA5106049
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TLR5 (Accession O60602), corresponding to amino acid residues around phosphorylated Tyr798 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817448 |
Product Specific Information
Antibody detects endogenous levels of TLR5 only when phosphorylated at Tyr798.
Target Information
TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents.
It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and inflammatory response.
TLR5 binds to TIRAP and MyD88 via their respective TIR domains. It is highly expressed in the liver, detected in the lung, and at very low levels in most other tissues.
The TLR5 gene locus is associated with susceptibility to Salmonella. Inbred mouse strains show varying resistance to S. typhimurium infection.
A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease, highlighting the importance of TLR5 in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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