Thermo Fisher Scientific Phospho-TLR5 (Tyr798) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of TLR5 only when phosphorylated at Tyr798.

Target Information

TLR5 is a Type I membrane protein belonging to the Toll-like receptor family and participates in the innate immune response to microbial agents.
It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and inflammatory response.
TLR5 binds to TIRAP and MyD88 via their respective TIR domains. It is highly expressed in the liver, detected in the lung, and at very low levels in most other tissues.
The TLR5 gene locus is associated with susceptibility to Salmonella. Inbred mouse strains show varying resistance to S. typhimurium infection.
A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease, highlighting the importance of TLR5 in innate immunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.