Thermo Fisher Scientific mGluR5 (extracellular) Polyclonal Antibody, Atto 594

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL of double distilled water (DDW), depending on the sample size.
• The antibody is shipped as a lyophilized powder at room temperature and should be stored at -20°C upon arrival.
• The reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family.
It phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes arrestin binding, which removes the receptor from G-protein interaction and terminates the signal chain.
GRK1 is farnesylated to promote membrane association. It can be inhibited by recoverin, a calcium-binding protein.
Dysfunction of GRK1 is associated with Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.